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Just to clear up a little more what this does:

When you're not in a NVME drive DirectStorage does "nothing" though it is required for the game to boot. For modded installs of GTA V DirectStore has to be nulled anyway because of the modded and added RPF files which will make the game create a new handle for each file, the fix does that, prevents it from running. So, this plugin makes GTA use OS' file cache, which leads to less disk access over time. Especially good for HDD. Less freezing, Less sound drop. I really have no idea if the Enhanced edition of GTA has these new no buffer flags because of the implementation of DirectStorage, the Legacy version obviously does and behaves just fine. Workloads in Games are pretty predictable. Like character animation, footstep sounds, textures or anything soon will eventually be used again and will not change. Therefore if engine properly cache by itself it wouldn't be any issue without the file cache. But with Direct Storage titles seems no longer, the system must read from disks whenever needed, which results in a considerable performance impact on slow drives like HDD or even conventional SATA SSD.

For a vanilla unmodded GTA Enhanced you're likely good but when you add mods and lots of RPFs and stuff things might change. Without the regular OS caching things could get unstable. On my end, this stopped my random crashes and got rid off my asset-streaming popping in despite having them maxed out in my graphics settings. I'm playing the game on a conventional HDD with a denser x2.5 gameconfig and a few mods which require of a higher heap limit.